Startup Showcase: Base Genomics

Revolutionizing Cancer Diagnosis with Innovative Epigenetic Technology


Welcome to, where we bring you the latest and most innovative startups from around the globe. In this edition, we shine the spotlight on Base Genomics, an epigenetics company based in Oxford, United Kingdom. Base Genomics is at the forefront of developing a groundbreaking blood test for early-stage cancer detection and minimal residual disease. Join us as we explore their pioneering work and the potential it holds for transforming cancer diagnosis.

Unveiling the Power of Epigenetics

Base Genomics is a trailblazer in the field of epigenetics, a branch of genetics that focuses on modifications to DNA that can influence gene expression without altering the underlying genetic code. By deciphering these modifications, known as DNA methylation, Base Genomics aims to uncover critical insights into the development and progression of cancer.

TAPS: A Game-Changing Technology

At the heart of Base Genomics’ innovation lies TAPS, or TET-assisted pyridine borane sequencing. Developed at the Ludwig Institute for Cancer Research Branch at the University of Oxford, TAPS revolutionizes DNA methylation analysis. Unlike traditional bisulfite sequencing, TAPS employs a novel chemical reaction that converts methylated cytosine to thymine under mild conditions. This innovative approach preserves DNA integrity, ensuring a greater quantity of DNA is available for sequencing.

Enhanced Precision, Reduced Costs

One of the key advantages of TAPS is its ability to enable simultaneous analysis of both epigenetic and genetic factors. This breakthrough allows researchers and clinicians to correlate genetic mutations with specific epigenetic modifications, providing a comprehensive view of cancer development. By combining these analyses, Base Genomics streamlines the diagnostic process, leading to more accurate and timely cancer detection.

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Moreover, TAPS significantly cuts down sequencing costs by retaining the complexity of DNA sequences. Researchers can now extract more information from a single sequencing run, maximizing efficiency and cost-effectiveness.

A New Era in Cancer Diagnosis

With its innovative technology, Base Genomics aims to transform the landscape of cancer diagnosis. By leveraging the power of epigenetics, their blood test has the potential to detect cancer at its earliest stages, improving patient outcomes and survival rates. Furthermore, the test can be used to monitor minimal residual disease, allowing for precise tracking of cancer progression and treatment effectiveness.


Base Genomics is at the forefront of the epigenetics revolution, utilizing their groundbreaking TAPS technology to unlock the secrets of DNA methylation. By providing a comprehensive understanding of cancer development, their blood test holds immense promise for early detection and monitoring of minimal residual disease. With Base Genomics leading the charge, we are entering a new era of precision medicine in the fight against cancer.





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